Protein Purification Reagents and Kits
Genscript Corporation CD14 His Human
Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters Given the absence of an intracellular tail CD14 was doubted to have the signaling capacities
Genscript Corporation SLAMF7/CRACC/CD319 His Cynom
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Genscript Corporation MSLN/Mesothelin296-598 His
Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF) Although it has been proposed that mesothelin may be involved in cell adhesion its biological function is not known A knockout mouse line that lacks mesothelin reproduces and develops normally
Genscript Corporation CEACAM-5/CD66e His Cynomolgu
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated
Genscript Corporation 4-1BB/TNFRSF9Biotin His A
4-1BB is also known as CD137 is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily CD137 can be expressed by activated T cells but to a larger extent on CD8 than on CD4 T cells In addition CD137 expression is found on dendritic cells B cells follicular dendritic cells natural killer cells granulocytes and cells of blood vessel walls at sites of inflammation
Cayman Chemical 5-fluoro nI 2-naphthyl Iso 5mg
A derivative of NNEI with a fluorine atom at the terminal carbon of the pentyl chain and the naphthyl group joined at the 2 rather than 1 position; intended for forensic and research applications
Genscript Corporation Her2/ErbB2 S310F His Human
ErbB2 also called Neu and Her2 (human epidermal growth factor receptor 2) is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors Upon ERBB2 activation the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane
Genscript Corporation CD96/TACTILEBiotin His Av
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
Cayman Chemical S-Acetyl-L-glutathIon 25g
A derivative of glutathione; more stable in plasma than GSH; converted to GSH by intracellular thioesterases; increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency at 50 μM; induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells at 5 mM; inhibits the replication of HSV-1 in human foreskin fibroblasts at 5 and 10 mM; increases survival in a mouse model of HSV-1 infection at 6.25 μg/g per day
Cayman Chemical DL-Sulforaphn GlutathIon 25mg
A metabolite of sulforaphane; increases mRNA expression of GSTA1 and UGT1A1 in HepG2 cells at 15 µM
Cayman Chemical DL-Sulforaphn GlutathIon 10mg
A metabolite of sulforaphane; increases mRNA expression of GSTA1 and UGT1A1 in HepG2 cells at 15 µM
ABclonal Technology Glutathione Peroxidase 2
The protein encoded by this gene is a member of the glutathione peroxidase family which reduces organic hydroperoxides and hydrogen peroxide (H2O2) using glutathione to protect against oxidative damage This isozyme is primarily expressed in the gastrointestinal tract and liver localized in the cytoplasm and prefers hydrogen peroxide as a substrate Overexpression is linked to increased differentiation and proliferation in colorectal cancer As a selenoprotein it contains selenocysteine (Sec) at its active site encoded by the UGA codon The 3 UTR of selenoprotein mRNAs has a Sec insertion sequence (SECIS) element enabling UGA to code for Sec instead of terminating translation Alternative splicing results in different transcript variants
UNIFIED INFORMATION DEVICES LLC MOUSE PROGRAM MICROCHIP 24/PK
NC2254993 MOUSE PROGRAM MICROCHIP 24/PK